BDBM321204 US10179123, Example 2-23
SMILES C[C@@H]1C[C@@H](CC(C)(C)C1)n1c(Cc2ccc(OC(F)(F)F)cc2)nc2cc(ccc12)C#N
InChI Key InChIKey=NHXZOSXJQFIJRX-APWZRJJASA-N
Data 1 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 1 hit for monomerid = 321204
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft
US Patent
Bayer Pharma Aktiengesellschaft
US Patent
Affinity DataIC50: 750nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair