BDBM32220 8-[5-(isopropylamino)pentylamino]quinolin-6-ol::8-[5-(propan-2-ylamino)pentylamino]-6-quinolinol::8-[5-(propan-2-ylamino)pentylamino]quinolin-6-ol::cid_408620

SMILES CC(C)NCCCCCNc1cc(O)cc2cccnc12

InChI Key InChIKey=FCQZEZCNARMPGO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 32220   

TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32220(8-[5-(isopropylamino)pentylamino]quinolin-6-ol | 8...)
Affinity DataIC50:  6.25E+3nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM32220(8-[5-(isopropylamino)pentylamino]quinolin-6-ol | 8...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of Hsp90 in human MCF7 cells assessed as Her2 level after 24 hrs by Western blotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM32220(8-[5-(isopropylamino)pentylamino]quinolin-6-ol | 8...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of Hsp90 in human MCF7 cell lysates assessed as interaction with Cy3b-conjugated geldanamycin by FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32220(8-[5-(isopropylamino)pentylamino]quinolin-6-ol | 8...)
Affinity DataIC50: >1.00E+4nMAssay Description:Emory Chemistry-Biology Discovery Center Assay Overview: MLSCN Grant: 1 X01MH78953-01 Hsp90 is a chaperon with important roles in maintaining transfo...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay