BDBM322638 2-phenyl-4-(4-(piperazin-1-yl) phenylamino)pyrimido[4,5-d]pyridazin- 5(6H)-one::US10183944, Example 8::US10647720, Ex. # 8

SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(cc3)N3CCNCC3)c12)-c1ccccc1

InChI Key InChIKey=SWGKFGZRXMXUDD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 322638   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Asana Biosciences

US Patent
LigandPNGBDBM322638(2-phenyl-4-(4-(piperazin-1-yl) phenylamino)pyrimid...)
Affinity DataIC50: <10nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Asan Biosciences

US Patent
LigandPNGBDBM322638(2-phenyl-4-(4-(piperazin-1-yl) phenylamino)pyrimid...)
Affinity DataIC50: <10nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Asana Biosciences

US Patent
LigandPNGBDBM322638(2-phenyl-4-(4-(piperazin-1-yl) phenylamino)pyrimid...)
Affinity DataIC50: <10nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Asan Biosciences

US Patent
LigandPNGBDBM322638(2-phenyl-4-(4-(piperazin-1-yl) phenylamino)pyrimid...)
Affinity DataIC50: <10nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent