BDBM322668 4-(4-(4-ethylpiperazin-1-yl)phenylamino)- 2-(thiophen-3-yl)pyrimido[4,5- d]pyridazin-5(6H)-one hydrochloride::US10183944, Example 37::US10647720, Ex. # 37

SMILES CCN1CCN(CC1)c1ccc(Nc2nc(nc3cn[nH]c(=O)c23)-c2ccsc2)cc1

InChI Key InChIKey=OLCKMCZRMYBMCH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 322668   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Asana Biosciences

US Patent
LigandPNGBDBM322668(4-(4-(4-ethylpiperazin-1-yl)phenylamino)- 2-(thiop...)
Affinity DataIC50: <10nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Asan Biosciences

US Patent
LigandPNGBDBM322668(4-(4-(4-ethylpiperazin-1-yl)phenylamino)- 2-(thiop...)
Affinity DataIC50:  75nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Asana Biosciences

US Patent
LigandPNGBDBM322668(4-(4-(4-ethylpiperazin-1-yl)phenylamino)- 2-(thiop...)
Affinity DataIC50: <10nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Asan Biosciences

US Patent
LigandPNGBDBM322668(4-(4-(4-ethylpiperazin-1-yl)phenylamino)- 2-(thiop...)
Affinity DataIC50: <100nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent