BDBM32540 arylsulfonylpiperazine, 12

SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1ccc(Cl)cc1

InChI Key InChIKey=GGTXCUVLRKFBHT-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 32540   

Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Amgen

LigandPNGBDBM32540(arylsulfonylpiperazine, 12)
Affinity DataIC50:  40nMAssay Description:Enzyme assays were performed using purified recombinant mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM32540(arylsulfonylpiperazine, 12)
Affinity DataIC50:  14nM EC50:  518nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed