BDBM3263 4-Anilino quinazoline deriv. 14::CHEMBL329672::CHEMBL555321::N-(3-chlorophenyl)quinazolin-4-amine

SMILES Clc1cccc(Nc2ncnc3ccccc23)c1

InChI Key InChIKey=ZKKVUIPXPPDIRD-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 3263   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3263(4-Anilino quinazoline deriv. 14 | CHEMBL329672 | C...)
Affinity DataIC50:  23nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3263(4-Anilino quinazoline deriv. 14 | CHEMBL329672 | C...)
Affinity DataIC50:  23nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3263(4-Anilino quinazoline deriv. 14 | CHEMBL329672 | C...)
Affinity DataIC50:  23nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM3263(4-Anilino quinazoline deriv. 14 | CHEMBL329672 | C...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of p56lck kinase autophosphorylation in Jurkat cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3263(4-Anilino quinazoline deriv. 14 | CHEMBL329672 | C...)
Affinity DataIC50:  23nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcyl-CoA (8-3)-desaturase(Homo sapiens (Human))
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM3263(4-Anilino quinazoline deriv. 14 | CHEMBL329672 | C...)
Affinity DataIC50:  11nMAssay Description:Inhibition of liver delta-5 desaturase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3263(4-Anilino quinazoline deriv. 14 | CHEMBL329672 | C...)
Affinity DataIC50:  50nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylation, 0.05-0.10More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3263(4-Anilino quinazoline deriv. 14 | CHEMBL329672 | C...)
Affinity DataIC50:  4.16E+3nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed