BDBM326704 (R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)-2-((5-(trifluoromethyl)pyridin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 421

SMILES FC(F)(F)c1ccc(OC2CC3CCC2N3C(=O)c2ccccc2-n2nccn2)nc1

InChI Key InChIKey=AXBDWANXRUPESE-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 326704   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM326704((R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)-2-((5-(tri...)
Affinity DataKi:  130nMAssay Description:Binding affinity to human OXIRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM326704((R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)-2-((5-(tri...)
Affinity DataKi:  154nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM326704((R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)-2-((5-(tri...)
Affinity DataKi:  205nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM326704((R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)-2-((5-(tri...)
Affinity DataKi:  2.70E+3nMAssay Description:Binding affinity to human OX2RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM326704((R/S)-(2-(2H-1,2,3-triazol-2-yl)phenyl)-2-((5-(tri...)
Affinity DataKi:  4.20E+3nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent