BDBM326730 (R/S)-(3-fluoro-2-(pyrimidin-2-yl)phenyl)(2-((5-(trifluoromethyl)pyrazin-2-yl)oxy)-7-azabicyclo[2.2.1]heptan-7-yl)methanone::US9637496, 447

SMILES Fc1cccc(C(=O)N2C3CCC2C(C3)Oc2cnc(cn2)C(F)(F)F)c1-c1ncccn1

InChI Key InChIKey=ZDDXQIUMQYDLCQ-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 326730   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM326730((R/S)-(3-fluoro-2-(pyrimidin-2-yl)phenyl)(2-((5-(t...)
Affinity DataKi:  100nMAssay Description:Binding affinity to human OXIRMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM326730((R/S)-(3-fluoro-2-(pyrimidin-2-yl)phenyl)(2-((5-(t...)
Affinity DataKi:  293nMAssay Description:Human Embryonic Kidney 293 cells (HEK293) stably expressing rat orexin 1 receptor (Genebank accession number NM_001525) or Chinese ovary cells (CHO) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM326730((R/S)-(3-fluoro-2-(pyrimidin-2-yl)phenyl)(2-((5-(t...)
Affinity DataKi:  5.50E+3nMAssay Description:Binding affinity to human OX2RMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM326730((R/S)-(3-fluoro-2-(pyrimidin-2-yl)phenyl)(2-((5-(t...)
Affinity DataKi: >1.00E+4nMAssay Description:HEK293 stably expressing human orexin 2 receptor (Genebank accession number NM_001526) were grown to confluency in DMEM (Hyclone, cat #SH30022), 10% ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent