BDBM327473 N((S)-2-fluoro-3-hydroxy-3-methylbutyl)-2-((S)-1-((4-fluorophenyl)sulfonyl)-6-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,2,3,4-tetrahydroquinolin-2-yl)acetamide::US9663469, 14
SMILES CC(C)(O)[C@H](F)CNC(=O)C[C@@H]1CCc2cc(ccc2N1S(=O)(=O)c1ccc(F)cc1)C(O)(C(F)(F)F)C(F)(F)F
InChI Key InChIKey=FQWMGYJHFABALZ-FXAWDEMLSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 327473
Affinity DataIC50: 22.1nMAssay Description:The binding of potential ligands to RORγ is measured by competition with [3H] 25-hydroxycholesterol using a scintillation proximity assay (SPA) ...More data for this Ligand-Target Pair
Affinity DataEC50: 39nMAssay Description:Inverse agonist activity at Gal4-tagged human RORgammat ligand binding domain expressed in human Jurkat cells by native IL17 promoter driven lucifera...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Bristol-Myers Squibb
Curated by ChEMBL
Bristol-Myers Squibb
Curated by ChEMBL
Affinity DataEC50: 2.00E+3nMAssay Description:Transactivation of PXR in human HepG2 cells by receptor transactivation assayMore data for this Ligand-Target Pair
Affinity DataEC50: >7.50E+3nMAssay Description:Agonist activity at GAL4-tagged human LXRalpha assessed as receptor activation expressed in African green monkey CV1 cells by luciferase reporter gen...More data for this Ligand-Target Pair
Affinity DataEC50: >7.50E+3nMAssay Description:Agonist activity at GAL4-tagged human LXRbeta assessed as receptor activation expressed in African green monkey CV1 cells by luciferase reporter gene...More data for this Ligand-Target Pair