BDBM330050 (1R,4S,12aR)-N-(2,4-difluorobenzyl)-7-hydroxy-6,8-dioxo-1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1′,2′-d]pyrazine-9-carboxamide::US10689399, Compound 47::US11548901, Compound 47::US9663528, 47::US9732092, Compound 47

SMILES Oc1c2C(=O)N3[C@H]4CC[C@H](C4)[C@@H]3Cn2cc(C(=O)NCc2ccc(F)cc2F)c1=O

InChI Key InChIKey=WKGDGYMWVQYBAY-HICWGWBUSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 330050   

TargetSolute carrier family 22 member 2(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM330050((1R,4S,12aR)-N-(2,4-difluorobenzyl)-7-hydroxy-6,8-...)
Affinity DataIC50:  6.20E+3nMAssay Description:The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 2(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM330050((1R,4S,12aR)-N-(2,4-difluorobenzyl)-7-hydroxy-6,8-...)
Affinity DataIC50:  6.20E+3nMAssay Description:The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPOU domain, class 2, transcription factor 2(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM330050((1R,4S,12aR)-N-(2,4-difluorobenzyl)-7-hydroxy-6,8-...)
Affinity DataIC50:  6.20E+3nMAssay Description:The dose dependent inhibition of OCT2 mediated uptake of a model substrate 14C-Tetraethylammonium (TEA) by test compounds was studied in wild-type an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSolute carrier family 22 member 2(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM330050((1R,4S,12aR)-N-(2,4-difluorobenzyl)-7-hydroxy-6,8-...)
Affinity DataIC50:  6.20E+3nMAssay Description:Test compounds were serially diluted in DMSO and then spiked (2 μL) into in 0.4 mL KHB buffer containing wild-type or OCT2-transfected cells and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent