BDBM330343 1-(3-{[(3R,6R)- 1-{[6-methoxy- 2-(2H-1,2,3- triazol-2-yl) pyridin-3-yl] carbonyl}-6- methyl- piperidin-3- yl]oxy} phenyl)ethanol::US9725434, 2::US9828368, Example 8

SMILES COc1ccc(C(=O)N2C[C@@H](CC[C@H]2C)Oc2cccc(c2)C(C)O)c(n1)-n1nccn1

InChI Key InChIKey=NZRHSDWEQBMOKT-XBOMOHCESA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 330343   

TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330343(1-(3-{[(3R,6R)- 1-{[6-methoxy- 2-(2H-1,2,3- triazo...)
Affinity DataIC50:  271nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330343(1-(3-{[(3R,6R)- 1-{[6-methoxy- 2-(2H-1,2,3- triazo...)
Affinity DataIC50:  1.00E+4nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330343(1-(3-{[(3R,6R)- 1-{[6-methoxy- 2-(2H-1,2,3- triazo...)
Affinity DataIC50:  890nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Rattus norvegicus (Rat))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330343(1-(3-{[(3R,6R)- 1-{[6-methoxy- 2-(2H-1,2,3- triazo...)
Affinity DataIC50:  1.08E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330343(1-(3-{[(3R,6R)- 1-{[6-methoxy- 2-(2H-1,2,3- triazo...)
Affinity DataIC50:  350nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330343(1-(3-{[(3R,6R)- 1-{[6-methoxy- 2-(2H-1,2,3- triazo...)
Affinity DataIC50:  18nMAssay Description:For intracellular calcium measurements, Chinese hamster ovary (CHO) cells expressing the rat orexin-1 receptor or the human orexin-2 receptor, are gr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent