BDBM330345 1-[3-({(3R,6R)-6-Methyl-1-[(2-pyrimidin-2-ylphenyl)carbonyl]piperidin-3-yl}oxy)phenyl]ethanol::US9725434, 3

SMILES CC(O)c1cccc(O[C@@H]2CC[C@@H](C)N(C2)C(=O)c2ccccc2-c2ncccn2)c1

InChI Key InChIKey=BRSKZHWDKMQWAQ-IIAQOEISSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 330345   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330345(1-[3-({(3R,6R)-6-Methyl-1-[(2-pyrimidin-2-ylphenyl...)
Affinity DataIC50:  4.24E+3nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330345(1-[3-({(3R,6R)-6-Methyl-1-[(2-pyrimidin-2-ylphenyl...)
Affinity DataIC50:  119nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent