BDBM333924 9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1- propanoylpyrrolidin-3-yl]oxy}- 9H-purine::US9730940, Compound 2-25

SMILES CCC(=O)N1CC[C@@H](C1)Oc1ncnc2n(CC)c(nc12)-c1cnc(C)nc1

InChI Key InChIKey=YNOLINLXOHNAOX-AWEZNQCLSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 333924   

LigandPNGBDBM333924(9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1- pr...)
Affinity DataIC50:  13nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM333924(9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1- pr...)
Affinity DataIC50:  13nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent