BDBM334012 9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1-(tetrahydrofuran- 3-ylcarbonyl)pyrrolidin-3- yl]oxy}-9H-purine::US9730940, Compound 2-113
SMILES CCn1c(nc2c(O[C@H]3CCN(C3)C(=O)C3CCOC3)ncnc12)-c1cnc(C)nc1
InChI Key InChIKey=ZJOFXUHWYKVIDA-WMCAAGNKSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 334012
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck
Curated by ChEMBL
Merck
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 5.80nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair