BDBM334012 9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1-(tetrahydrofuran- 3-ylcarbonyl)pyrrolidin-3- yl]oxy}-9H-purine::US9730940, Compound 2-113

SMILES CCn1c(nc2c(O[C@H]3CCN(C3)C(=O)C3CCOC3)ncnc12)-c1cnc(C)nc1

InChI Key InChIKey=ZJOFXUHWYKVIDA-WMCAAGNKSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 334012   

LigandPNGBDBM334012(9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1-(te...)
Affinity DataIC50:  6nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM334012(9-ethyl-8-(2-methylpyrimidin-5- yl)-6-{[(3S)-1-(te...)
Affinity DataIC50:  5.80nMAssay Description:The PI3-Kinase biochemical assay was optimized using the HTRF kit provided by Upstate (Millipore). The assay kit contains six reagents: 1) 4× Reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent