BDBM334583 US11040966, Example 2.9::US9732075, Example 2.8::[(S)-2-(5-Chloro-4-methyl-1H-benzoimidazol-2-yl)-4,4-difluoro-pyrrolidin-1-yl]-(2-methyl-5-phenyl-thiazol-4-yl)-methanone

SMILES Cc1nc(C(=O)N2CC(F)(F)C[C@H]2c2nc3c(C)c(Cl)ccc3[nH]2)c(s1)-c1ccccc1

InChI Key InChIKey=RVNZOLZTRBRTRZ-KRWDZBQOSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 334583   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM334583(US11040966, Example 2.9 | US9732075, Example 2.8 |...)
Affinity DataIC50:  70nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM334583(US11040966, Example 2.9 | US9732075, Example 2.8 |...)
Affinity DataIC50:  18nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM334583(US11040966, Example 2.9 | US9732075, Example 2.8 |...)
Affinity DataIC50:  17nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM334583(US11040966, Example 2.9 | US9732075, Example 2.8 |...)
Affinity DataIC50:  51nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent