BDBM335238 US11040966, Example 6.192::US9732075, Example 6.191::[(S)-2-(5,6-Dimethyl-1H-benzoimidazol-2-yl)-4-methylene-pyrrolidin-1-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone

SMILES Cc1cc2nc([nH]c2cc1C)[C@@H]1CC(=C)CN1C(=O)c1c(F)cccc1-n1nccn1

InChI Key InChIKey=ZYFAPCPVLVCAGT-FQEVSTJZSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 335238   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM335238(US11040966, Example 6.192 | US9732075, Example 6.1...)
Affinity DataIC50:  134nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM335238(US11040966, Example 6.192 | US9732075, Example 6.1...)
Affinity DataIC50:  48nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM335238(US11040966, Example 6.192 | US9732075, Example 6.1...)
Affinity DataIC50:  7nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent