BDBM335318 US11040966, Example 6.87::US9732075, Example 6.87::rac-(2-Cyclopropyl-5-m-tolyl-thiazol-4-yl)-[4-methylene-2-(7-methylsulfanyl-1H-benzoimidazol-2-yl)-pyrrolidin-1-yl]-methanone

SMILES CSc1cccc2nc([nH]c12)C1CC(=C)CN1C(=O)c1nc(sc1-c1cccc(C)c1)C1CC1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 335318   

TargetOrexin receptor type 2(Homo sapiens (Human))
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM335318(US11040966, Example 6.87 | US9732075, Example 6.87...)
Affinity DataIC50:  2nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM335318(US11040966, Example 6.87 | US9732075, Example 6.87...)
Affinity DataIC50:  1nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent