BDBM342905 1-(3'-chloro-2-fluoro-5-methoxy-4-biphenylyl)-N-3-isoxazolyl-6-isoquinolinesulfonamide::US9776995, Example 116

SMILES COc1cc(c(F)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cccc(Cl)c1

InChI Key InChIKey=CLDQISWQQGUYBE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 342905   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM342905(1-(3'-chloro-2-fluoro-5-methoxy-4-biphenylyl)-N-3-...)
Affinity DataIC50:  16.3nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM342905(1-(3'-chloro-2-fluoro-5-methoxy-4-biphenylyl)-N-3-...)
Affinity DataIC50:  37nMAssay Description:Binding affinity towards rat forebrain nicotinic acetylcholine receptor using [3H]EB as radioligandMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM342905(1-(3'-chloro-2-fluoro-5-methoxy-4-biphenylyl)-N-3-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells assessed as reduction in peak inward current by ionworks quattro electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM342905(1-(3'-chloro-2-fluoro-5-methoxy-4-biphenylyl)-N-3-...)
Affinity DataIC50: >1.00E+4nMAssay Description:293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent