BDBM3487 3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin-1-yl)propyl]amino}pyrido[2,3-d]pyrimidin-7-yl]-1-(4-methoxyphenyl)urea::6-arylpyrido[2,3-d]pyrimidine deriv. 69::CHEMBL298679

SMILES COc1ccc(NC(=O)Nc2nc3nc(NCCCN4CCN(C)CC4)ncc3cc2-c2c(Cl)cccc2Cl)cc1

InChI Key InChIKey=LVEXBQONPVYXPA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 3487   

TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pfizer

LigandPNGBDBM3487(3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin...)
Affinity DataIC50:  680nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM3487(3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin...)
Affinity DataIC50:  74nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM3487(3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin...)
Affinity DataIC50:  793nMAssay Description:Inhibitory concentration of compound against mouse Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM3487(3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin...)
Affinity DataIC50:  720nMAssay Description:Inhibition of human epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM3487(3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin...)
Affinity DataIC50:  28nMAssay Description:Inhibition of chicken c-Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Pfizer

LigandPNGBDBM3487(3-[6-(2,6-dichlorophenyl)-2-{[3-(4-methylpiperazin...)
Affinity DataIC50:  33nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed