BDBM350006 6-(3-amino-6-(1- (4,4,4-trifluoro-2- hydroxybutyl)-1H- pyrazol-4yl)pyrazin- 2-yl)-2-(3,5- dimethoxyphenyl) pyridazin-3(2H)-one::US10208024, Example 5::US10766881, Example 5

SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC(O)CC(F)(F)F)c1

InChI Key InChIKey=ODVWBADYBXDOHC-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 350006   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM350006(6-(3-amino-6-(1- (4,4,4-trifluoro-2- hydroxybutyl)...)
Affinity DataIC50:  17nMAssay Description:FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM350006(6-(3-amino-6-(1- (4,4,4-trifluoro-2- hydroxybutyl)...)
Affinity DataIC50:  3.20nMAssay Description:FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3 [397-806](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM350006(6-(3-amino-6-(1- (4,4,4-trifluoro-2- hydroxybutyl)...)
Affinity DataIC50:  2.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1 [308-731](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM350006(6-(3-amino-6-(1- (4,4,4-trifluoro-2- hydroxybutyl)...)
Affinity DataIC50:  17nMAssay Description:To measure FGFR1 kinase activity, 200 pM His-tagged recombinant human FGFR1 catalytic domain (amino acids 308-731) (Life Technologies Cat. No. PR4660...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2 [403-822](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM350006(6-(3-amino-6-(1- (4,4,4-trifluoro-2- hydroxybutyl)...)
Affinity DataIC50:  3.20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM350006(6-(3-amino-6-(1- (4,4,4-trifluoro-2- hydroxybutyl)...)
Affinity DataIC50:  2.90nMAssay Description:FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent