BDBM350016 6-(3-amino-6-(1- isopropyl-1H-pyrazol- 4-yl)pyrazin-2-yl)-2- (3,5- dimethoxyphenyl)pyridazin- 3(2H)-one 2,2,2-trifluoroacetate::US10208024, Example 15::US10766881, Example 15

SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C(C)C

InChI Key InChIKey=DWXMGHZIWRZUMA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 350016   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM350016(6-(3-amino-6-(1- isopropyl-1H-pyrazol- 4-yl)pyrazi...)
Affinity DataIC50:  17.4nMAssay Description:FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM350016(6-(3-amino-6-(1- isopropyl-1H-pyrazol- 4-yl)pyrazi...)
Affinity DataIC50:  3.70nMAssay Description:FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3 [397-806](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM350016(6-(3-amino-6-(1- isopropyl-1H-pyrazol- 4-yl)pyrazi...)
Affinity DataIC50:  7nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1 [308-731](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM350016(6-(3-amino-6-(1- isopropyl-1H-pyrazol- 4-yl)pyrazi...)
Affinity DataIC50:  17.4nMAssay Description:To measure FGFR1 kinase activity, 200 pM His-tagged recombinant human FGFR1 catalytic domain (amino acids 308-731) (Life Technologies Cat. No. PR4660...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2 [403-822](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM350016(6-(3-amino-6-(1- isopropyl-1H-pyrazol- 4-yl)pyrazi...)
Affinity DataIC50:  3.70nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM350016(6-(3-amino-6-(1- isopropyl-1H-pyrazol- 4-yl)pyrazi...)
Affinity DataIC50:  7nMAssay Description:FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent