BDBM350022 6-(3-amino-6-(1- isobutyl-1H-pyrazol- 4-yl)pyrazin-2-yl)-2- (3,5- dimethoxyphenyl) pyridazin-3(2H)-one::US10208024, Example 21::US10766881, Example 21

SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(CC(C)C)c1

InChI Key InChIKey=GYSNMOKUABWZLQ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 350022   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM350022(6-(3-amino-6-(1- isobutyl-1H-pyrazol- 4-yl)pyrazin...)
Affinity DataIC50:  39.1nMAssay Description:FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM350022(6-(3-amino-6-(1- isobutyl-1H-pyrazol- 4-yl)pyrazin...)
Affinity DataIC50:  7.5nMAssay Description:FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3 [397-806](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM350022(6-(3-amino-6-(1- isobutyl-1H-pyrazol- 4-yl)pyrazin...)
Affinity DataIC50:  4.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1 [308-731](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM350022(6-(3-amino-6-(1- isobutyl-1H-pyrazol- 4-yl)pyrazin...)
Affinity DataIC50:  39.1nMAssay Description:To measure FGFR1 kinase activity, 200 pM His-tagged recombinant human FGFR1 catalytic domain (amino acids 308-731) (Life Technologies Cat. No. PR4660...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2 [403-822](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM350022(6-(3-amino-6-(1- isobutyl-1H-pyrazol- 4-yl)pyrazin...)
Affinity DataIC50:  7.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM350022(6-(3-amino-6-(1- isobutyl-1H-pyrazol- 4-yl)pyrazin...)
Affinity DataIC50:  4.90nMAssay Description:FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen™ Assay technology which directly measures the amount of substrate phosphor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent