BDBM35223 pyrimidoindolone, 25d

SMILES O=C1C2=NCC3(CCCC3)CN2c2ccc(cc12)S(=O)(=O)N1CCC[C@H]1COc1ccccc1

InChI Key InChIKey=YQTVACGCXXQPQH-IBGZPJMESA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 35223   

TargetCaspase-3(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35223(pyrimidoindolone, 25d)
Affinity DataIC50:  2.32nMT: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed