BDBM352484 US10745364, Example 2C::US9809561, 2C::[(R)-4-(3-chloro-benzenesulfonyl)-2- hydroxymethyl-3,4-dihydro-2H- benzo[1,4]oxazin-6-yl]-carbamic acid tert-butyl ester
SMILES CC(C)(C)OC(=O)Nc1ccc2O[C@@H](CO)CN(c2c1)S(=O)(=O)c1cccc(Cl)c1
InChI Key InChIKey=WMYHWVQAEMHQEQ-OAHLLOKOSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 352484
Affinity DataIC50: 4.57nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
Affinity DataIC50: 4.57nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Affinity DataIC50: 4.57nMAssay Description:HIS-tagged RORγ-LBD protein was recombinantly expressed in Escherichia coli. The RORγ-LBD protein was purified by Ni2+-affinity resin. Puri...More data for this Ligand-Target Pair