BDBM352540 (S)-1,1,1-trifluoro-2-methylpropan-2-yl (4-((3-chloro-1-ethyl-1H-pyrazol-4- yl)sulfonyl)-2-(((N- methylsulfamoyl)amino)methyl)-3,4- dihydro-2H-benzo[b][1,4]oxazin-6- yl)carbamate::US10745364, Example 13AB::US9809561, 13AB
SMILES CCn1cc(c(Cl)n1)S(=O)(=O)N1C[C@H](CNS(=O)(=O)NC)Oc2ccc(NC(=O)OC(C)(C)C(F)(F)F)cc12
InChI Key InChIKey=FSCPIHBPYSGBMI-ZDUSSCGKSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 352540
Affinity DataIC50: 3.92nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
Affinity DataIC50: 3.92nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Affinity DataIC50: 3.92nMAssay Description:HIS-tagged RORγ-LBD protein was recombinantly expressed in Escherichia coli. The RORγ-LBD protein was purified by Ni2+-affinity resin. Puri...More data for this Ligand-Target Pair