BDBM352544 (S)-1,1,1-trifluoro-2-methylpropan-2-yl (4-((2-methoxy-5,6-dihydro-4H- pyrrolo[1,2-b]pyrazol-3-yl)sulfonyl)-2- (((N-methylsulfamoyl)amino)methyl)- 3,4-dihydro-2H-benzo[b][1,4]oxazin-6- yl)carbamate::US10745364, Example 13AF::US9809561, 13AF
SMILES CNS(=O)(=O)NC[C@H]1CN(c2cc(NC(=O)OC(C)(C)C(F)(F)F)ccc2O1)S(=O)(=O)c1c(OC)nn2CCCc12
InChI Key InChIKey=OCEIZLQMUPRIKW-AWEZNQCLSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 352544
Affinity DataIC50: 3.93nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
Affinity DataIC50: 3.93nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Affinity DataIC50: 3.93nMAssay Description:HIS-tagged RORγ-LBD protein was recombinantly expressed in Escherichia coli. The RORγ-LBD protein was purified by Ni2+-affinity resin. Puri...More data for this Ligand-Target Pair