BDBM352619 (S)-tert-butyl (4-((3-chloro-4- fluorophenyl) sulfonyl)-2-(2- (methylamino)-2-oxoethyl)- 3,4-dihydro- 2H-benzo[b][1,4] oxazin-6-yl)carbamate::US10745364, Example 37H::US9809561, 37H
SMILES CNC(=O)C[C@H]1CN(c2cc(NC(=O)OC(C)(C)C)ccc2O1)S(=O)(=O)c1ccc(F)c(Cl)c1
InChI Key InChIKey=FTOKLVWMRBWTNV-AWEZNQCLSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 352619
Affinity DataIC50: 2.81nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
Affinity DataIC50: 2.81nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Affinity DataIC50: 2.81nMAssay Description:HIS-tagged RORγ-LBD protein was recombinantly expressed in Escherichia coli. The RORγ-LBD protein was purified by Ni2+-affinity resin. Puri...More data for this Ligand-Target Pair