BDBM352630 (S)-tert-butyl (2- (2-(((1-ethyl-1H- pyrazol-3-yl)methyl) amino)-2-oxoethyl)- 4-((3-(trifluoromethyl) phenyl)sulfonyl)- 3,4-dihydro-2H- benzo[b][1,4]oxazin-6- yl)carbamate::US10745364, Example 37S::US9809561, 37S
SMILES CCn1ccc(CNC(=O)C[C@H]2CN(c3cc(NC(=O)OC(C)(C)C)ccc3O2)S(=O)(=O)c2cccc(c2)C(F)(F)F)n1
InChI Key InChIKey=UEKSFDQUHQBWEQ-NRFANRHFSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 352630
Affinity DataIC50: 4.47nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
Affinity DataIC50: 4.47nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Affinity DataIC50: 4.47nMAssay Description:HIS-tagged RORγ-LBD protein was recombinantly expressed in Escherichia coli. The RORγ-LBD protein was purified by Ni2+-affinity resin. Puri...More data for this Ligand-Target Pair