BDBM352630 (S)-tert-butyl (2- (2-(((1-ethyl-1H- pyrazol-3-yl)methyl) amino)-2-oxoethyl)- 4-((3-(trifluoromethyl) phenyl)sulfonyl)- 3,4-dihydro-2H- benzo[b][1,4]oxazin-6- yl)carbamate::US10745364, Example 37S::US9809561, 37S

SMILES CCn1ccc(CNC(=O)C[C@H]2CN(c3cc(NC(=O)OC(C)(C)C)ccc3O2)S(=O)(=O)c2cccc(c2)C(F)(F)F)n1

InChI Key InChIKey=UEKSFDQUHQBWEQ-NRFANRHFSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 352630   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352630((S)-tert-butyl (2- (2-(((1-ethyl-1H- pyrazol-3-yl)...)
Affinity DataIC50:  4.47nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352630((S)-tert-butyl (2- (2-(((1-ethyl-1H- pyrazol-3-yl)...)
Affinity DataIC50:  4.47nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352630((S)-tert-butyl (2- (2-(((1-ethyl-1H- pyrazol-3-yl)...)
Affinity DataIC50:  4.47nMAssay Description:HIS-tagged RORγ-LBD protein was recombinantly expressed in Escherichia coli. The RORγ-LBD protein was purified by Ni2+-affinity resin. Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent