BDBM352744 (R)-1,1,1-trifluoro-2-methylpropan-2-yl (2-(2-(2-oxopyrrolidin-1-yl)ethyl)-4-((3- (trifluoromethyl)phenyl)sulfonyl)-3,4- dihydro-2H-benzo[b][1,4]oxazin-6- yl)carbamate::US10745364, Example 53P::US9809561, 53P

SMILES CC(C)(OC(=O)Nc1ccc2O[C@H](CCN3CCCC3=O)CN(c2c1)S(=O)(=O)c1cccc(c1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=LNPJUZHJUCJWDB-GOSISDBHSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 352744   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352744((R)-1,1,1-trifluoro-2-methylpropan-2-yl (2-(2-(2-o...)
Affinity DataIC50:  3.42nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352744((R)-1,1,1-trifluoro-2-methylpropan-2-yl (2-(2-(2-o...)
Affinity DataIC50:  3.42nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352744((R)-1,1,1-trifluoro-2-methylpropan-2-yl (2-(2-(2-o...)
Affinity DataIC50:  3.42nMAssay Description:HIS-tagged RORγ-LBD protein was recombinantly expressed in Escherichia coli. The RORγ-LBD protein was purified by Ni2+-affinity resin. Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent