BDBM352905 2,2,2-trifluoro-1,1- dimethylethyl {l-[(3- chloro-1-ethyl-1H-pyrazol- 4-yl)sulfonyl]-1,2,3,4- tetrahydroquinolin-7- yl}carbamate::US10745364, Example 114A::US9809561, 114A::US9809561, 118
SMILES CCn1cc(c(Cl)n1)S(=O)(=O)N1CCCc2ccc(NC(=O)OC(C)(C)C(F)(F)F)cc12
InChI Key InChIKey=RLMHELJJJIKERR-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 352905
Affinity DataIC50: 3.87nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
Affinity DataIC50: 3.87nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Affinity DataIC50: 3.87nMAssay Description:HIS-tagged RORγ-LBD protein was recombinantly expressed in Escherichia coli. The RORγ-LBD protein was purified by Ni2+-affinity resin. Puri...More data for this Ligand-Target Pair
Affinity DataIC50: 720nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair