BDBM352908 2,2,2-trifluoro-1,1- dimethylethyl (1-{[2- (trifluoromethyl)pyridin-4- yl]sulfonyl}-1,2,3,4- tetrahydroquinolin-7- yl)carbamate::US10745364, Example 114D::US9809561, 114D

SMILES CC(C)(OC(=O)Nc1ccc2CCCN(c2c1)S(=O)(=O)c1ccnc(c1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=ANCOQONFZLLAHL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 352908   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352908(2,2,2-trifluoro-1,1- dimethylethyl (1-{[2- (triflu...)
Affinity DataIC50:  3.46nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., a biochemical TR-FRET assay....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352908(2,2,2-trifluoro-1,1- dimethylethyl (1-{[2- (triflu...)
Affinity DataIC50:  3.46nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM352908(2,2,2-trifluoro-1,1- dimethylethyl (1-{[2- (triflu...)
Affinity DataIC50:  3.46nMAssay Description:HIS-tagged RORγ-LBD protein was recombinantly expressed in Escherichia coli. The RORγ-LBD protein was purified by Ni2+-affinity resin. Puri...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent