BDBM3556 4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline::CHEMBL1204199::CHEMBL35820::N-(3-bromophenyl)-6,7-diethoxyquinazolin-4-amine::PD153035 Analog::PD153035 Analog 56

SMILES CCOc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OCC

InChI Key InChIKey=YXOXHAUUTIOBDA-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 3556   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3556(4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline |...)
Affinity DataIC50:  0.00600nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3556(4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline |...)
Affinity DataIC50:  0.00603nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Sus scrofa (Pig))
Pfizer

Curated by ChEMBL
LigandPNGBDBM3556(4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline |...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM3556(4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline |...)
Affinity DataIC50:  1.70E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3556(4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline |...)
Affinity DataIC50:  0.00600nMAssay Description:Inhibition of wild type EGFRChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Lawrence Berkeley National Laboratory

Curated by ChEMBL
LigandPNGBDBM3556(4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline |...)
Affinity DataIC50:  215nMAssay Description:Inhibition of human ErbB2 tyrosine kinase phosphorylation expressed in mouse BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3556(4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline |...)
Affinity DataIC50:  0.410nMAssay Description:Displacement of [125I]4-(3-iodoanilino)-6,7-dimethoxyquinazoline from EGFR tyrosine kinase in human A431 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3556(4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline |...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human EGFR tyrosine kinase phosphorylation expressed in mouse BaF3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Lawrence Berkeley National Laboratory

Curated by ChEMBL
LigandPNGBDBM3556(4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline |...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human ErbB4 tyrosine kinase phosphorylation expressed in human CEM/4 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM3556(4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline |...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound was evaluated for its concentration required to inhibit the rat liver F16BPaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed