BDBM35644 erk000524::pyrimidylpyrrole, 9c

SMILES CCc1ccccc1Nc1ncc(C)c(n1)-c1c[nH]c(c1)C(=O)N[C@H](CO)c1ccccc1

InChI Key InChIKey=PDGBJOHNOOKHMI-HSZRJFAPSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 35644   

TargetMitogen-activated protein kinase 1(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35644(erk000524 | pyrimidylpyrrole, 9c)
Affinity DataKi:  3nM ΔG°:  -11.8kcal/molepH: 7.5 T: 30°CAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35644(erk000524 | pyrimidylpyrrole, 9c)
Affinity DataKi:  3nMAssay Description:Assay 1 ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMitogen-activated protein kinase 1(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35644(erk000524 | pyrimidylpyrrole, 9c)
Affinity DataKi:  3nMAssay Description:Photometric_Method2More data for this Ligand-Target Pair
In DepthDetails D3R

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35644(erk000524 | pyrimidylpyrrole, 9c)
Affinity DataKi:  210nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35644(erk000524 | pyrimidylpyrrole, 9c)
Affinity DataKi:  760nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Human)
Vertex Pharmaceuticals

LigandPNGBDBM35644(erk000524 | pyrimidylpyrrole, 9c)
Affinity DataKi:  1.43E+3nMAssay Description:A coupled spectrophotometric assay was used in which ADP generated by kinase was converted to ATP with the concomitant production of pyruvate from PE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed