BDBM357139 (Z)-5-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)-2-(24-((methoxycarbonyl)amino)-4-oxo-11H-3-aza-1(4,2)-imidazola-2(1,2) -benzenacyclononaphane-9-yl)pyridine 1-oxide::US10214512, Example 98-a

SMILES COC(=O)Nc1ccc2-c3c[nH]c(n3)C(CCCCC(=O)Nc2c1)c1ccc(c[n+]1[O-])-c1cc(Cl)ccc1-n1cnnn1

InChI Key

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 357139   

TargetKallikrein-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357139((Z)-5-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)-2-(24-...)
Affinity DataKi:  0.490nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357139((Z)-5-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)-2-(24-...)
Affinity DataKi:  0.510nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent