BDBM357149 (Z)-2-(24-Amino-4-OXO-11H-3-aza-1(4,2)-imidazola-2(1,2) -benzenacyclononaphane-9-yl)-5-(3-chloro-2,6-difluorophenyl)pyridine 1-oxide::US10214512, Example 108-a

SMILES Nc1ccc2-c3c[nH]c(n3)C(CCCCC(=O)Nc2c1)c1ccc(c[n+]1[O-])-c1c(F)ccc(Cl)c1F

InChI Key

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 357149   

TargetCoagulation factor XI(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357149((Z)-2-(24-Amino-4-OXO-11H-3-aza-1(4,2)-imidazola-2...)
Affinity DataKi:  0.180nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Coagulation Factor XIa can be determined using a relevant purified serine...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKallikrein-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM357149((Z)-2-(24-Amino-4-OXO-11H-3-aza-1(4,2)-imidazola-2...)
Affinity DataKi:  1.02nMAssay Description:The effectiveness of a compound of the present invention as an inhibitor of Kallikrein can be determined using a relevant purified serine protease, a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent