BDBM357894 US10214536, Compound 76

SMILES Nc1nc2oc3ccc(cc3c(=O)c2cc1C(O)=O)C1CCS(=O)(=O)CC1

InChI Key InChIKey=YLXHHSZCWBYDQH-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 357894   

TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM357894(US10214536, Compound 76)
Affinity DataIC50:  170nMAssay Description:Kinase assays are commonly used for determining the ability of a small molecule to inhibit enzyme activity. By measuring the degree of phosphorylatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM357894(US10214536, Compound 76)
Affinity DataIC50:  830nMAssay Description:Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM357894(US10214536, Compound 76)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed