BDBM357914 2-Amino-8-fluoro-7-isopropyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid::US10214536, Compound 272

SMILES CC(C)c1cc2c(cc1F)oc1nc(N)c(cc1c2=O)C(O)=O

InChI Key InChIKey=ZAFOQCLNYNBOQC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 357914   

TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM357914(2-Amino-8-fluoro-7-isopropyl-5-oxo-5H-chromeno[2,3...)
Affinity DataIC50:  1.24E+3nMAssay Description:Kinase assays are commonly used for determining the ability of a small molecule to inhibit enzyme activity. By measuring the degree of phosphorylatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM357914(2-Amino-8-fluoro-7-isopropyl-5-oxo-5H-chromeno[2,3...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM357914(2-Amino-8-fluoro-7-isopropyl-5-oxo-5H-chromeno[2,3...)
Affinity DataIC50:  5.37E+3nMAssay Description:Inhibition of human IKKepsilon (1 to 655 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in pres...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM357914(2-Amino-8-fluoro-7-isopropyl-5-oxo-5H-chromeno[2,3...)
Affinity DataIC50:  398nMAssay Description:Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM357914(2-Amino-8-fluoro-7-isopropyl-5-oxo-5H-chromeno[2,3...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human TBK1 (1 to 657 residues) expressed in Baculovirus infected SF9 insect cells using myelin basic protein as substrate in presence o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed