BDBM358691 (S)-1-(5-(4-amino-5-chloropyrrolo [2,1-f][1,2,4]triazin-7-yl)-2- fluorophenyl)-3,3,6-trimethyl-4-(2- (methylsulfonyl)acetyl)piperazin-2-one::US10214537, Example 769

SMILES C[C@H]1CN(C(=O)CS(C)(=O)=O)C(C)(C)C(=O)N1c1cc(ccc1F)-c1cc(Cl)c2c(N)ncnn12

InChI Key InChIKey=VEYFBNORVXDVCH-LBPRGKRZSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 358691   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM358691((S)-1-(5-(4-amino-5-chloropyrrolo [2,1-f][1,2,4]tr...)
Affinity DataIC50:  0.200nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent