BDBM358966 (6R,8aS)-6-(8-amino-1- {4-[(1R)-1-(3- cyclopropylphenyl)-1- hydroxyethyl]-3- methoxyphenyl}imidazo [1,5-a]pyrazin-3- yl)hexahydroindolizin- 3(2H)-one::US10214546, Example 98

SMILES COc1cc(ccc1[C@](C)(O)c1cccc(c1)C1CC1)-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12

InChI Key InChIKey=HUFWGNOUYCORNX-QVVQTHAHSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 358966   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM358966((6R,8aS)-6-(8-amino-1- {4-[(1R)-1-(3- cyclopropylp...)
Affinity DataIC50:  0.280nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent