BDBM358989 (6R,8aS)-6-[8-amino-5- chloro-1-(4-{(1R)-1- hydroxy-1-[3-(2,2,2- trifluoroethyl)phenyl] ethyl}phenyl)imidazo[1,5- a]pyrazin-3- yl]hexahydroindolizin- 3(2H)-one::US10214546, Example 121

SMILES C[C@@](O)(c1ccc(cc1)-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(Cl)cnc(N)c12)c1cccc(CC(F)(F)F)c1

InChI Key InChIKey=DTHHDLICAQVDEJ-GUDDLILSSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 358989   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM358989((6R,8aS)-6-[8-amino-5- chloro-1-(4-{(1R)-1- hydrox...)
Affinity DataIC50:  0.180nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent