BDBM359012 (6R,8aS)-6-[8-amino-1- (4-{1-[3- (difluoromethoxy)phenyl]- 1-hydroxyethyl}phenyl) imidazo[1,5-a]pyrazin-3- yl]hexahydroindolizin- 3(2H)-one::US10214546, Example 144::US10214546, Example 148

SMILES CC(O)(c1ccc(cc1)-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2ccnc(N)c12)c1cccc(OC(F)F)c1

InChI Key InChIKey=AWSYJQHGDFQVQU-VGEZZCLVSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 359012   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM359012((6R,8aS)-6-[8-amino-1- (4-{1-[3- (difluoromethoxy)...)
Affinity DataIC50:  0.200nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM359012((6R,8aS)-6-[8-amino-1- (4-{1-[3- (difluoromethoxy)...)
Affinity DataIC50:  67.6nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent