BDBM359029 (6S,8aR)-6-[8-amino-1- (4-{(1R)-1-hydroxy-1-[3- (trifluoromethyl)phenyl] ethyl}phenyl)imidazo [1,5-a]pyrazin-3-yl]-1,1- dimethylhexahydroindolizin- 3(2H)-one::US10214546, Example 161::US10214546, Example 163

SMILES C[C@@](O)(c1ccc(cc1)-c1nc([C@H]2CC[C@H]3N(C2)C(=O)CC3(C)C)n2ccnc(N)c12)c1cccc(c1)C(F)(F)F

InChI Key InChIKey=BKZNWRLLDUNXGN-YNCULORESA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 359029   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM359029((6S,8aR)-6-[8-amino-1- (4-{(1R)-1-hydroxy-1-[3- (t...)
Affinity DataIC50:  169nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM359029((6S,8aR)-6-[8-amino-1- (4-{(1R)-1-hydroxy-1-[3- (t...)
Affinity DataIC50:  0.270nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent