BDBM359046 (6R.8aS)-6-[8-amino-1- (4-{(1R)-1-[3- (difluoromethyl)phenyl]-1- hydroxyethyl}phenyl)- 5-fluoroimidazo[1,5- a]pyrazin-3-yl]-2,2- dimethylhexahydroindolizin- 3(2H)-one::US10214546, Example 178

SMILES C[C@@](O)(c1ccc(cc1)-c1nc([C@@H]2CC[C@H]3CC(C)(C)C(=O)N3C2)n2c(F)cnc(N)c12)c1cccc(c1)C(F)F

InChI Key InChIKey=JBGGEYBUAOOWQE-MNSNBHKMSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 359046   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM359046((6R.8aS)-6-[8-amino-1- (4-{(1R)-1-[3- (difluoromet...)
Affinity DataIC50:  1.30nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent