BDBM359050 (1R,6R,8aS)-6-[8- amino-1-(4-{(1R)-1-[3- (difluoromethyl)phenyl]-1- hydroxyethyl}phenyl) imidazo[1,5-a]pyrazin- 3-yl]-1- (trifluoromethyl) hexahydroindolizin-3(2H)- one::US10214546, Example 182::US10214546, Example 184

SMILES C[C@@](O)(c1ccc(cc1)-c1nc([C@@H]2CC[C@H]3C(CC(=O)N3C2)C(F)(F)F)n2ccnc(N)c12)c1cccc(c1)C(F)F

InChI Key InChIKey=FUZSNLSJUYKJHS-VYKGGNLFSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 359050   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM359050((1R,6R,8aS)-6-[8- amino-1-(4-{(1R)-1-[3- (difluoro...)
Affinity DataIC50:  1.40nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM359050((1R,6R,8aS)-6-[8- amino-1-(4-{(1R)-1-[3- (difluoro...)
Affinity DataIC50:  0.430nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent