BDBM359067 (6R,8aS)-6-(8-amino-1- (4-{(1R)-1-[3- (difluoromethyl)phenyl]-1- hydroxyethyl}phenyl)- 5-fluoroimidazo[1,5- a]pyrazin-3- yl]hexahydroindolizin- 3(2H)-one::US10214546, Example 199

SMILES C[C@@](O)(c1ccc(cc1)-c1nc([C@@H]2CC[C@H]3CCC(=O)N3C2)n2c(F)cnc(N)c12)c1cccc(c1)C(F)F

InChI Key InChIKey=PWDWKKXUAJBSBY-OVPJMRJESA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 359067   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM359067((6R,8aS)-6-(8-amino-1- (4-{(1R)-1-[3- (difluoromet...)
Affinity DataIC50:  0.660nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent