BDBM35929 2,2-Diphenyl-ethylamine::2,2-diphenylethanamine::2,2-diphenylethylamine::CHEMBL10780::EN300-13160::diphenylalkylamine (DPA), 4a

SMILES NCC(c1ccccc1)c1ccccc1

InChI Key InChIKey=RXMTUVIKZRXSSM-UHFFFAOYSA-N

Data  5 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 35929   

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM35929(2,2-Diphenyl-ethylamine | 2,2-diphenylethanamine |...)
Affinity DataKi:  4.61E+3nMAssay Description:Binding affinity of the compound was performed using [3H]-ketanserin as the radioligand and stably transfected NIH3T3 cells expressing the 5-hydroxyt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM35929(2,2-Diphenyl-ethylamine | 2,2-diphenylethanamine |...)
Affinity DataKi:  4.61E+3nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM35929(2,2-Diphenyl-ethylamine | 2,2-diphenylethanamine |...)
Affinity DataKi:  4.61E+3nM ΔG°:  -7.23kcal/molepH: 7.4 T: 2°CAssay Description:Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM35929(2,2-Diphenyl-ethylamine | 2,2-diphenylethanamine |...)
Affinity DataKi:  5.70E+3nMAssay Description:Binding affinity against 5-hydroxytryptamine 2A receptor expressed NIH3T3 cells using [3H]-ketanserinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Virginia Commonwealth University

LigandPNGBDBM35929(2,2-Diphenyl-ethylamine | 2,2-diphenylethanamine |...)
Affinity DataKi: >1.00E+4nM ΔG°: >-6.82kcal/moleT: 2°CAssay Description:Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM35929(2,2-Diphenyl-ethylamine | 2,2-diphenylethanamine |...)
Affinity DataIC50:  5.82E+3nMAssay Description:IC50 values were determined for the whole plate in case of Chan-Lam coupling, using 5 point 3-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTrace amine-associated receptor 1(Homo sapiens (Human))
Rti International

Curated by ChEMBL
LigandPNGBDBM35929(2,2-Diphenyl-ethylamine | 2,2-diphenylethanamine |...)
Affinity DataEC50:  3.40E+3nMAssay Description:Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed