BDBM360932 4-(2-aminobenzo [d]thiazol-4-yl)- N1-(2-azabicyclo [2.2.1]heptan- 6-yl)-3-(1H- tetrazol-5- yl)benzene-1,2- disulfonamide::US10221163, Example 88::US10221163, Example 89::US10544130, Example 89

SMILES Nc1nc2c(cccc2s1)-c1ccc(c(c1-c1nnn[nH]1)S(N)(=O)=O)S(=O)(=O)NC1CC2CNC1C2

InChI Key

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 360932   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360932(4-(2-aminobenzo [d]thiazol-4-yl)- N1-(2-azabicyclo...)
Affinity DataIC50:  0.172nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360932(4-(2-aminobenzo [d]thiazol-4-yl)- N1-(2-azabicyclo...)
Affinity DataIC50:  0.0200nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVIM-1 metallo-beta-lactamase(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360932(4-(2-aminobenzo [d]thiazol-4-yl)- N1-(2-azabicyclo...)
Affinity DataIC50:  0.165nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360932(4-(2-aminobenzo [d]thiazol-4-yl)- N1-(2-azabicyclo...)
Affinity DataIC50:  0.568nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360932(4-(2-aminobenzo [d]thiazol-4-yl)- N1-(2-azabicyclo...)
Affinity DataIC50:  0.0580nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase()
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360932(4-(2-aminobenzo [d]thiazol-4-yl)- N1-(2-azabicyclo...)
Affinity DataIC50:  0.230nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360932(4-(2-aminobenzo [d]thiazol-4-yl)- N1-(2-azabicyclo...)
Affinity DataIC50:  0.172nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360932(4-(2-aminobenzo [d]thiazol-4-yl)- N1-(2-azabicyclo...)
Affinity DataIC50:  0.0200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-lactamase()
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360932(4-(2-aminobenzo [d]thiazol-4-yl)- N1-(2-azabicyclo...)
Affinity DataIC50:  0.165nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360932(4-(2-aminobenzo [d]thiazol-4-yl)- N1-(2-azabicyclo...)
Affinity DataIC50:  0.568nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetallo-beta-lactamase type 2(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360932(4-(2-aminobenzo [d]thiazol-4-yl)- N1-(2-azabicyclo...)
Affinity DataIC50:  0.0580nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVIM-1 metallo-beta-lactamase(Klebsiella pneumoniae)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM360932(4-(2-aminobenzo [d]thiazol-4-yl)- N1-(2-azabicyclo...)
Affinity DataIC50:  0.230nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent