BDBM361458 2,2-difIuoro-3- ((1R,3R)-1-(5- ((S)-2-((3- fluoropropyl) amino)propoxy)- 2- methoxyphenyl)- 3-methyl- 1,3,4,9- tetrahydro-2H- pyrido[3,4- b]indol-2- yl)propan-1-ol::US10221173, Example 50::US10590132, Example 50::US11046689, Example 50

SMILES COc1ccc(OC[C@@H](C)NCCCF)cc1[C@H]1N(CC(F)(F)CO)[C@H](C)Cc2c1[nH]c1ccccc21

InChI Key

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 361458   

TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM361458(2,2-difIuoro-3- ((1R,3R)-1-(5- ((S)-2-((3- fluorop...)
Affinity DataIC50:  1nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha—LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM361458(2,2-difIuoro-3- ((1R,3R)-1-(5- ((S)-2-((3- fluorop...)
Affinity DataIC50:  0.810nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM361458(2,2-difIuoro-3- ((1R,3R)-1-(5- ((S)-2-((3- fluorop...)
Affinity DataIC50:  5.30E+3nMAssay Description:hERG (human ether a go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM361458(2,2-difIuoro-3- ((1R,3R)-1-(5- ((S)-2-((3- fluorop...)
Affinity DataIC50:  5.30E+3nMAssay Description:hERG (human ether a go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM361458(2,2-difIuoro-3- ((1R,3R)-1-(5- ((S)-2-((3- fluorop...)
Affinity DataIC50:  5.30E+3nMAssay Description:hERG: The purpose of the hERG binding assay is to evaluate the effects of test compounds on the voltage-dependent potassium channel encoded by the hu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM361458(2,2-difIuoro-3- ((1R,3R)-1-(5- ((S)-2-((3- fluorop...)
Affinity DataIC50:  1nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha-LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor [307-554](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM361458(2,2-difIuoro-3- ((1R,3R)-1-(5- ((S)-2-((3- fluorop...)
Affinity DataIC50:  1nMAssay Description:ERα: The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha-LBD (GST)) was assessed in competition...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent