BDBM361460 3-fluoro-N-(2- (3-((1R,3R)-2- ((1- fluorocyclopropyl) methyl)-3- methyl- 2,3,4,9- tetrahydro-1H- pyrido[3,4- b]indol-1-yl)- 4- methoxyphenoxy) ethyl)propan- 1-amine::US10221173, Example 52::US10590132, Example 52::US11046689, Example 52
SMILES COc1ccc(OCCNCCCF)cc1[C@H]1N(CC2(F)CC2)[C@H](C)Cc2c1[nH]c1ccccc21
InChI Key
Data 7 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 361460
Affinity DataIC50: 0.580nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha—LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
Affinity DataIC50: 0.340nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca
US Patent
Astrazeneca
US Patent
Affinity DataIC50: 5.50E+3nMAssay Description:hERG (human ether a go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca
US Patent
Astrazeneca
US Patent
Affinity DataIC50: 5.50E+3nMAssay Description:hERG (human ether a go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a ...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca
US Patent
Astrazeneca
US Patent
Affinity DataIC50: 5.50E+3nMAssay Description:hERG: The purpose of the hERG binding assay is to evaluate the effects of test compounds on the voltage-dependent potassium channel encoded by the hu...More data for this Ligand-Target Pair
Affinity DataIC50: 0.580nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha-LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
Affinity DataIC50: 0.580nMAssay Description:ERα: The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha-LBD (GST)) was assessed in competition...More data for this Ligand-Target Pair