BDBM362831 3-(Butylamino)-5-(trans-4-hydroxycyclohexyl)-8-[(tetrahydro-2H-pyran-4-ylamino) methyl]pyrimido[4,5-c]isoquinolin-6(5H)-one::US9840503, Example 4

SMILES CCCCNc1ncc2c3ccc(CNC4CCOCC4)cc3c(=O)n([C@H]3CC[C@H](O)CC3)c2n1

InChI Key InChIKey=UNCDTDAPDXLQLM-MEMLXQNLSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 362831   

TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM362831(3-(Butylamino)-5-(trans-4-hydroxycyclohexyl)-8-[(t...)
Affinity DataIC50: >1.00E+3nMAssay Description:The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM362831(3-(Butylamino)-5-(trans-4-hydroxycyclohexyl)-8-[(t...)
Affinity DataIC50:  550nMAssay Description:The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM362831(3-(Butylamino)-5-(trans-4-hydroxycyclohexyl)-8-[(t...)
Affinity DataIC50: <100nMAssay Description:The assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.5 ul test compounds dissolved in DMSO were transfe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent